Design, Synthesis and Biological Evaluation ofnovel lipoamino acid-based glycolipids for oral drug delivery.
Falconer, Robert A. Toth, I.
Falconer, Robert A.
Toth, I.
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2007
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Abstract
A series of lipoamino acid-based glycolipids were synthesised. Suitably derivatised lipoamino acid derivatives were prepared and conjugated to monosaccharides (including glycosyl azides, isothiocyanates, thiols and sulphones) to yield novel O-, N-, S- and C-linked glycolipids in good yields. Their potential to improve the oral absorption of piperacillin is reported.
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Falconer, R.A. and Toth, I. (2007). Design, Synthesis and Biological Evaluation ofnovel lipoamino acid-based glycolipids for oral drug delivery. Bioorganic & Medicinal Chemistry. Vol. 15, No. 22, pp. 7012-7020.
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