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Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
Zhang, J. Ma, A. Shang, Lijun
Zhang, J.
Ma, A.
Shang, Lijun
Publication Date
2018-05-29
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© 2018 Zhang, Ma and Shang. This is an open-access article distributed
under the terms of the Creative Commons Attribution License (CC BY). The use,
distribution or reproduction in other forums is permitted, provided the original
author(s) and the copyright owner are credited and that the original publication
in this journal is cited, in accordance with accepted academic practice. No use,
distribution or reproduction is permitted which does not comply with these terms.
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openAccess
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2018-05-11
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Abstract
Developing new methods to treat heart diseases is always a focus for basic research
and clinical applications. Existing drugs have strong side-effects and also require
lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in
treating atherosclerosis in animals and some heart diseases such as heart failure
and endocarditis have provided hopes for better drug delivery and reducing of drug
side-effects. In this mini-review, we summarize the present applications of using
gold nanoparticles (GNPs) as a new drug delivery system in diseased hearts and
of the assessment of toxicity in using GNPs. We suggest that conjugating existing
clinical drugs with GNPs is a favorable choice to provide “new and double-enhanced”
potentiality to those existing drugs in treating heart diseases. Other applications of using
NPs in the treatment of heart diseases including using drugs in nano-form and coating
drugs with a surface of relevant NP are also discussed.
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Citation
Zhang J, Ma A and Shang L (2018) Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases. Frontiers in Physiology. 9:642.
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Article