Loading...
Using out-of-office blood pressure measurements in established cardiovascular risk scores: implications for practice
Stevens, S.L. Stevens, R.J. de Leeuw, P. Kroon, A.A. Greenfield, S. Mohammed, Mohammed A. Gill, P. Verberk, W.J. McManus, R.J.
Stevens, S.L.
Stevens, R.J.
de Leeuw, P.
Kroon, A.A.
Greenfield, S.
Mohammed, Mohammed A.
Gill, P.
Verberk, W.J.
McManus, R.J.
Publication Date
2018
End of Embargo
Supervisor
Rights
© 2019 Royal College of General Practitioners. Reproduced in accordance with the publisher's self-archiving policy.
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2018-09-07
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Blood pressure (BP) measurement is increasingly carried out through home or ambulatory monitoring, yet existing cardiovascular risk scores were developed for use with measurements obtained in clinic.
To describe differences in cardiovascular risk estimates obtained using ambulatory or home BP measurements instead of clinic readings.
Design and setting: Secondary analysis of data from adults aged 30-84 without prior history of cardiovascular disease (CVD) in two BP monitoring studies (BP-Eth and HOMERUS).
Method: The primary comparison was Framingham risk calculated using BP measured as in the Framingham study or daytime ambulatory BP measurements. The QRISK2 and SCORE risk equations were also studied. Statistical and clinical significance were determined using the Wilcoxon signed-rank test and scatter plots respectively.
Results: In 442 BP-Eth patients (mean age = 58 years, 50% female) the median absolute difference in 10-year Framingham cardiovascular risk calculated using BP measured as in the Framingham study or daytime ambulatory BP measurements was 1.84% (interquartile range 0.65 to 3.63, p=0.67). Only 31/ 442 (7.0%) of patients were reclassified across the 10% risk treatment threshold. In 165 HOMERUS patients (mean age = 56 years, 46% female) the median difference in 10-year risk was 2.76% (IQR 1.19 to 6.39, p<0.001) and only 8/165 (4.8%) of patient were reclassified.
Conclusion: Estimates of cardiovascular risk are similar when calculated using BP measurements obtained as in the risk score derivation study or through ambulatory monitoring. Further research is required to determine if differences in estimated risk would meaningfully influence risk score accuracy.
Version
Accepted manuscript
Citation
Stevens SL, Stevens RJ, de Leeuw P et al (2019) Using out-of-office blood pressure measurements in established cardiovascular risk scores: implications for practice. British Journal of General Practice. 69(683): e381-e388.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article