Nanomedicines targeting the inflammasome as a promising therapeutic approach for cell senescence
Chaturvedi, S. Naseem, Z.
Chaturvedi, S.
Naseem, Z.
Publication Date
2022-11
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© 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Yes
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openAccess
Accepted for publication
2022-08-22
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Abstract
Technological advancements in the present era have enhanced drug discovery and development. Nanomedicines are valuable pharmacotherapeutic tools against several diseases and disorders including aging related disorders. The mechanistic association between nanomedicines and molecular modulation have been investigated by many researchers. Notwithstanding the availability of tremendous amount of data, role of nanomedicines in aging related disorders intending inflammasome transfiguration have not been thoroughly reviewed till now. In the present review, we discuss the application of nanomedicines in aging related disorders. Further, we highlight the recent updates on modulated upstream and downstream signalling molecules of inflammasome cascade due to nanomedicines. The review will benefit researchers targeting nanomedicines as a therapeutic approach towards treatment age related disorders through inflammasome inflection.
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Published version
Citation
Chaturvedi S, Naseem Z, El-Khamisy SF et al (2022) Nanomedicines targeting the inflammasome as a promising therapeutic approach for cell senescence. Seminars in Cancer Biology. 86(Pt 2): 46-53.
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Article