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Poloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performance
Vigato, A.A. Sepulveda, A.F. Machado, I.P. Ribeiro de Araujo, D.
Vigato, A.A.
Sepulveda, A.F.
Machado, I.P.
Ribeiro de Araujo, D.
Publication Date
2023-08
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Ā© 2023 International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature. Reproduced in accordance with the publisher's self-archiving policy. The final publication is available at Springer via https://doi.org/10.1007/s12551-023-01093-2.
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openAccess
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2023-06-30
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Abstract
Poloxamers or PluronicsĀ®-based nanogels are one of the most used matrices for developing delivery systems. Due to their thermoresponsive and flexible mechanical properties, they allowed the incorporation of several molecules including drugs, biomacromolecules, lipid-derivatives, polymers, and metallic, polymeric, or lipid nanocarriers. The thermogelling mechanism is driven by micelles formation and their self-assembly as phase organizations (lamellar, hexagonal, cubic) in response to microenvironmental conditions such as temperature, osmolarity, and additives incorporated. Then, different biophysical techniques have been used for investigating those structural transitions from the mechanisms to the preferential componentās orientation and organization. Since the design of PL-based pharmaceutical formulations is driven by the choice of the polymer type, considering its physico-chemical properties, it is also relevant to highlight that factors inherent to the polymeric matrix can be strongly influenced by the presence of additives and how they are able to determine the nanogels biopharmaceuticals properties such as bioadhesion, drug loading, surface interaction behavior, dissolution, and release rate control. In this review, we discuss the general applicability of three of the main biophysical techniques used to characterize those systems, scattering techniques (small-angle X-ray and neutron scattering), rheology and Fourier transform infrared absorption spectroscopy (FTIR), connecting their supramolecular structure and insights for formulating effective therapeutic delivery systems.
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Accepted manuscript
Citation
Shriky B, Vigato AA, Sepulveda AF et al (2023) Poloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performance. Biophysical Reviews. 15(4): 475-496.
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