Implication of drug repurposing in the identification of antibacterial agents
Jha, Vibhu Eriksson, L.A.
Jha, Vibhu
Eriksson, L.A.
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2023-09-01
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Abstract
Significant efforts have been made over the last decade with regards to the repurposing of existing drugs for new and unexplored therapeutic indications. In comparison to the conventional drug discovery process, which is time-consuming and expensive, drug repurposing is proven to be a cost-effective strategy due to pre-established pharmacokinetic profile of the existing candidates. With particular reference to antibacterial drug discovery, enormous challenges are nowadays seen due to the development of severe drug resistance with the use of antibiotics against both gram-positive and gramnegative bacteria such as multidrug-resistant tuberculosis (MDR-TB) with isoniazid and rifampicin, methicillin-resistant S. aureus (MRSA), and S. pseudintermedius (MRSP), vancomycin- resistant Enterococcus (VRE), etc. New and more effective ways are therefore needed to overcome the drug resistance associated with antibiotics. Drug repurposing, which is characterized by reduced risk, timeline, and cost to a drug discovery process, can be thus considered as a promising alternative strategy to combat multidrug-resistant bacterial infections (MDRBIs). Furthermore, drug repurposing opens an affordable opportunity for the growth of small-scale and medium-scale companies rather than just limiting it to the big pharmaceutical companies. In this review, we have discussed a broad category of existing drugs: anti-hyperlipidemia, anticancer, antiparasitic, antifungal, antimalarial and anti-inflammatory drugs that have been repurposed to treat bacterial infections. The authors believe that the notable outcomes from the case studies discussed in this work will further guide researchers working in the development of new antibacterial agents by drug repurposing approach.
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Jha V and Eriksson LA (2023) Implication of drug repurposing in the identification of antibacterial agents. In: Drug Repurposing, edited by Ramarao Poduri et al. Berlin, Boston: De Gruyter. pp. 115-138.
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