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Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression
Williams, Jamie J.L. Munro, K.M.A. Palmer, Timothy M.
Williams, Jamie J.L.
Munro, K.M.A.
Palmer, Timothy M.
Publication Date
30/05/2014
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(c) 2014 The Authors. Full-text reproduced in accordance with the publisher's self-archiving policy. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/
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openAccess
Accepted for publication
04/05/2014
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Abstract
The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3), its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.
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Published version
Citation
Williams JJL, Munro KMA and Palmer TM (2014) Role of Ubiquitylation in Controlling
Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression. Cells. 3(2): 546-562.
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Article