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Methyl (S)-3-((1r*,3R*)-3-((1H-indol-3-yl)methyl)cyclobutane-1-carboxamido)-2-(phenylsulfonamido)propanoate
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Publication Date
2026-07-01
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© 2026 The Author(s). This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)
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2026-06-29
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sheldrake_2026.pdf
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Abstract
The cyclobutane ring has attractive properties as a scaffold in medicinal chemistry but is underused, potentially due to the limited methods available for synthesising highly functionalised cyclobutanes. This short note describes the synthesis of the 1,3-cis disubstituted cyclobutane, methyl (S)-3-((1r*,3R*)-3-((1H-indol-3-yl)methyl)cyclobutane-1-carboxamido)-2-(phenylsulfonamido)propanoate using a one-pot thermal stepwise cycloaddition reaction and its characterisation by NMR spectroscopy and HRMS.
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Sheldrake H (2026) Methyl (S)-3-((1r*,3R*)-3-((1H-indol-3-yl)methyl)cyclobutane-1-carboxamido)-2-(phenylsulfonamido)propanoate. MolBank. 2026: 4.
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