Biarylpyrimidines: a new class of ligand for high-order DNA recognition
Murphy, Peter M. Phillips, Victoria A. Jennings, Sharon A. Garbett, N.C. Chaires, J.B. Jenkins, Terence C. Wheelhouse, Richard T.
Murphy, Peter M.
Phillips, Victoria A.
Jennings, Sharon A.
Garbett, N.C.
Chaires, J.B.
Jenkins, Terence C.
Wheelhouse, Richard T.
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2003
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Abstract
Biarylpyrimidines bearing ω-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.
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Murphy PM, Phillips VA, Jennings SA, et al (2003) Biarylpyrimidines: a new class of ligand for high-order DNA recognition. Chemical Communications. 2003 (10): 1160-1161.
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