Publication

Probing linker design in citric acid-ciprofloxacin conjugates

Milner, S.J.
; 
Snelling, Anna M.
; 
Kerr, Kevin G.
; 
Abd-El-Aziz, A.
; 
Thomas, G.H.
; 
Hubbard, R.E.
; 
Routledge, A.
; 
Duhme-Klair, A-K.
Publication Date
2014
End of Embargo
Supervisor
Keywords
Siderophore, Citrate, Antibiotic, Computational modelling
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Life Sciences Publications
Show all metadata
Abstract
A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.
URI
http://hdl.handle.net/10454/10512
Version
No full-text in the repository
Citation
Milner SJ, Snelling AM, Kerr KG et al (2014) Probing linker design in citric acid-ciprofloxacin conjugates. Bioorganic and Medicinal Chemistry. 22(16): 4499-4505.
Link to publisher’s version
Link to published version
Link to Version of Record
https://doi.org/10.1016/j.bmc.2014.04.009
Type
Article
Qualification name
Notes