Loading...
pH Responsive Highly Branched Poly(N-isopropylacrylamide) with Trihistidine or Acid Chain Ends
Lapworth, J. Swindells, K. Swanson, L. Rimmer, Stephen
Lapworth, J.
Swindells, K.
Swanson, L.
Rimmer, Stephen
Citations
Altmetric:
Publication Date
2016
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2016-07-06
Institution
Department
Awarded
Embargo end date
Collections
Files
Loading...
swift_et_al_2016.pdf
Adobe PDF, 1.09 MB
Additional title
Abstract
Thermally responsive highly branched poly(N-isopropyl acrylamide)s (HB-PNIPAM) were prepared and end-functionalised
to give polymers with acid or trihistidine end groups. These polymers exhibit a broad coil-to-globule transition across a
wide temperature range which can be measured using covalently attached fluorescent tags. The acid chain ends provided
a material with a distinct change in solution behaviour at pH close to the pKa of the carboxylate group. At pH 11 this
polymer did not show a cloud point up to 50 °C but fluorescence measurements on the labelled polymers showed that a
coil to glubule transition did take place. The globular state, above the LCST, appeared to be more swollen if the end group
carried charge then when it was uncharged. A polymer with trihistidine and free carboxylate chain ends, which contained
multiple charges at various pH, did show LCSTs at all pH and the polymer globule was shown to be swollen at each pH.
Version
Accepted manuscript
Citation
Swift T, Lapworth J, Swindells K et al (2016) pH responsive highly branched poly(N-isopropylacrylamide) with trihistidine or acid chain ends. RSC Advances. 75: 71345-71350.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article