Construction of DNA–polymer hybrids using intercalation interactions
Wilks, T.R. Pitto-Barry, Anaïs Kirby, N. Stulz, E. O'Reilly, R.K.
Wilks, T.R.
Pitto-Barry, Anaïs
Kirby, N.
Stulz, E.
O'Reilly, R.K.
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2013-12-17
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Abstract
Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.
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Wilks TR, Pitto-Barry A, Kirby N, Stulz E and O'Reilly RK (2014) Chemical Communications. 50: 1338-1340.
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