The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.
Lisgarten, J.N. Coll, M. Portugal, J. Wright, Colin W. Aymami, J.
Lisgarten, J.N.
Coll, M.
Portugal, J.
Wright, Colin W.
Aymami, J.
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2001
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Abstract
Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites. Here we show that cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)2 in a base-stacking intercalation mode.
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Lisgarten, J. N., Coll, M., Portugal, J., Wright, C. W. and Aymami, J. (2001). The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. Nature Structural Biology, Vol. 9, pp. 57 - 60.
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