Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes
Pettenuzzo, A. Attia, A.A.A. Lupan, A. Ronconi, L.
Pettenuzzo, A.
Attia, A.A.A.
Lupan, A.
Ronconi, L.
Publication Date
2023-08-21
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© 2023 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0)
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2023-07-07
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Abstract
The synthesis by transmetallation and in-depth characterisation by IR spectroscopy of five half-sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.
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Soldevila‐Barreda JJ, Pettenuzzo A, Azmanova M et al (2023) Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes. Helvetica Chimica Acta. 106(8): e202300064.
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