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Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
Clare, L. Bayer, A. Burns, A. Corbett, A. Jones, R. Knapp, M. Kopelman, M.D. Kudlicka, A. Leroi, I.
Clare, L.
Bayer, A.
Burns, A.
Corbett, A.
Jones, R.
Knapp, M.
Kopelman, M.D.
Kudlicka, A.
Leroi, I.
Publication Date
2013-05-27
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(c) 2013 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/deed.en)
© 2013 Clare, L. et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
© 2013 Clare, L. et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically
effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers.
This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with
early-stage dementia and their carers.
Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage
dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation
(10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the
effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and
carer-rated goal performance in areas identified as causing concern by people with early-stage dementia;
improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress
levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental
cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined.
Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important
to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine
health-care provision. Our aim is to provide training and develop materials to support the implementation of this
approach following trial completion.
Trial registration: Current Controlled Trials ISRCTN21027481
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Published version
Citation
Clare L, Bayer A, Burns A et al (2013) Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials. 14: 152.
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