Loading...
A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A
Bailey, C.S. Zarins-Tutt, J.S. Agbo, M. Gao, H. Diego-Taboada, A. Gan, M. Hamed, Refaat B. Abraham, E.R. Mckenzie, G. Evans, P.A.
Bailey, C.S.
Zarins-Tutt, J.S.
Agbo, M.
Gao, H.
Diego-Taboada, A.
Gan, M.
Hamed, Refaat B.
Abraham, E.R.
Mckenzie, G.
Evans, P.A.
Publication Date
2019-08-28
End of Embargo
Supervisor
Rights
(c) 2019 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc/3.0/)
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2019-05-20
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly short half-life in natural light, which severely impacts their potential biological utility given that they display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture broths that contain the marinomycins, which provides a significantly higher recovery than with conventional XAD resins and provides concomitant photoprotection.
Version
Published version
Citation
Bailey CS, Zarins-Tutt JS, Agbo M et al (2019) A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A. Chemical Science. 10(32): 7549-7553.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article