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Synthesis of caffeine/maleic acid co-crystal by ultrasound assisted slurry co-crystallization
Apshingekar, Prafulla P. Aher, Suyog Kelly, Adrian L.
Apshingekar, Prafulla P.
Aher, Suyog
Kelly, Adrian L.
Publication Date
2017-01, 2017-01
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© 2017 Wiley. This is the peer-reviewed version of the following article: Apshingekar PP, Aher S, Kelly AL, Brown EC and Paradkar A (2016) Synthesis of caffeine/maleic acid co-crystal by ultrasound assisted slurry co-crystallization. Journal of Pharmaceutical Sciences. , which has been published in final form at xxxxxx. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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2016-09-06
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Abstract
A green approach has been used for co-crystallization of non-congruent co-crystal pair of caffeine – maleic acid using water. Ultrasound is known to affect crystallization hence the effect of high power ultrasound on the ternary phase diagram has been investigated in detail using a slurry co-crystallization approach. A systematic investigation was performed to understand how the accelerated conditions during ultrasound assisted co-crystallization will affect different regions of the ternary phase diagram. Application of ultrasound showed considerable effect on the ternary phase diagram; principally on caffeine/maleic acid 2:1 (disappeared) and 1:1 co-crystal (narrowed) regions. Also, the stability regions for pure caffeine and maleic acid in water were narrowed in the presence of ultrasound, expanding the solution region. The observed effect of ultrasound on the phase diagram was correlated with solubility of caffeine and maleic acid and stability of co-crystal forms in water.
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Accepted manuscript
Citation
Apshingekar PP, Aher S, Kelly AL, Brown EC and Paradkar AR (2017) Synthesis of caffeine/maleic acid co-crystal by ultrasound assisted slurry co-crystallization. Journal of Pharmaceutical Sciences. 106(1): 66-70.
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