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Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity
Barry, Nicolas P.E. Pitto-Barry, Anaïs Romero-Canelón, I. Tran, J. Soldevila-Barreda, Joan J. Hands-Portman, I. Smith, C.J. Kirby, N. Dove, A.P. O'Reilly, R.K.
Barry, Nicolas P.E.
Pitto-Barry, Anaïs
Romero-Canelón, I.
Tran, J.
Soldevila-Barreda, Joan J.
Hands-Portman, I.
Smith, C.J.
Kirby, N.
Dove, A.P.
O'Reilly, R.K.
Publication Date
2014
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© 2014 The Royal Society of Chemistry. Reproduced in accordance with
the publisher's self-archiving policy. This article is licensed under a Creative Commons
Attribution 3.0 Unported Licence.
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openAccess
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2014-06-16
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Abstract
We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core–shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells.
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Published version
Citation
Barry NPE, Pitto-Barry A, Romero-Canelón I et al (2014) Precious metal carborane
polymer nanoparticles: characterisation of micellar formulations and anticancer activity. Faraday
Discussions. 175: 229-240.
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Article