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Synthesis of sulfonamide-based ynamides and ynamines in water
Zhao, L. Yang, H. Li, R. Tao, Y. Guo, X-F. Anderson, E.A. Whiting, A.
Zhao, L.
Yang, H.
Li, R.
Tao, Y.
Guo, X-F.
Anderson, E.A.
Whiting, A.
Publication Date
2021-01
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© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.0c02326.
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openAccess
Accepted for publication
11/12/2020
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Abstract
Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.
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Accepted manuscript
Citation
Zhao L, Yang H, Li r et al (2021) Synthesis of sulfonamide-based ynamides and ynamines in water. Journal of Organic Chemistry. 86(2): 1938-1947.
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Article