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Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity

Sanni, O.
; 
Chang, Chien-Yi
; 
Anderson, D.G.
; 
Langer, R.
; 
Davies, M.C.
; 
Williams, P.M.
; 
Williams, P.
; 
Alexander, M.R.
; 
Hook, A.L.
Publication Date
2015-04-02
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Supervisor
Keywords
Low-fouling, Molecular descriptors, Polymer microarrays, Pseudomonas aeruginosa, Ion mass spectrometry
Rights
© 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Yes
Open Access status
openAccess
Accepted for publication
2014
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Department
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Life Sciences Publications
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Abstract
A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria is explored, comparing cyclic, aromatic, and linear chemical groups. A correlation is shown between bacterial attachment and a parameter derived from the partition coefficient and the number of rotatable bonds of the materials' pendant groups. This correlation is applicable to 86% of the hydrocarbon pendant moieties surveyed, quantitatively supporting the previous qualitative observation that bacteria are repelled from poly(meth)acrylates containing a hydrophilic ester group when the pendant group is both rigid and hydrophobic. This insight will help inform and predict the further development of polymers resistant to bacterial attachment.
URI
http://hdl.handle.net/10454/15067
Version
Published version
Citation
Sanni O, Chang C, Anderson DG et al (2015) Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity. Advanced Healthcare Materials. 4(5): 695- 701.
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Link to published version
Link to Version of Record
https://doi.org/10.1002/adhm.201400648
Type
Article
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