Loading...
Human S-cone electroretinograms obtained by silent substitution stimulation
Maguire, John Parry, Neil R.A. Kremers, Jan Murray, I.J. McKeefry, Declan J.
Maguire, John
Parry, Neil R.A.
Kremers, Jan
Murray, I.J.
McKeefry, Declan J.
Publication Date
29/01/2018
End of Embargo
Supervisor
Rights
(c) 2018 OSA. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
27/12/2017
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
We used triple silent substitution stimuli to characterize human S-cone electroretinograms (ERGs) in normal trichromats. Short-wavelength-cone (S-cone) ERGs were found to have different morphological features and temporal frequency response characteristics compared to ERGs derived from L-cones, M-cones, and rod photoreceptors in normal participants. Furthermore, in two cases of retinal pathology, blue cone monochromatism (BCM) and enhanced S-cone syndrome (ESCS), S-cone ERGs elicited by our stimuli were preserved and enhanced, respectively. The results from both normal and pathological retinae demonstrate that triple silent substitution stimuli can be used to generate ERGs that provide an assay of human S-cone function.
Version
Accepted manuscript
Citation
Maguire J, Parry NRA, Kremers J et al (2018) Human S-cone electroretinograms obtained by silent substitution stimulation. JOSA A. 35(4): B11-B18.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article