Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity
Hamed, Refaat B. Gomez-Castellanos, J.R. Sean Froese, D. Krysztofinska, E. Yue, W.W. Schofield, C.J.
Hamed, Refaat B.
Gomez-Castellanos, J.R.
Sean Froese, D.
Krysztofinska, E.
Yue, W.W.
Schofield, C.J.
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15/03/2016
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The use of methylmalonyl-CoA epimerase (MCEE) to improve stereoselectivity in crotonase-mediated biocatalysis is exemplified by the coupling of MCEE, crotonyl-CoA carboxylase reductase and carboxymethylproline synthase in a three-enzyme one-pot sequential synthesis of functionalised C-5 carboxyalkylprolines starting from crotonyl-CoA and carbon dioxide.
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Hamed RB, Gomez-castellanos JR, Sean Froese D et al (2016) Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity. ChemBioChem. 17(6): 471-473.
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