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Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery
Osman, N. Roman, S. Sefat, Farshid Bullock, A.J. Chapple, C.R.
Osman, N.
Roman, S.
Sefat, Farshid
Bullock, A.J.
Chapple, C.R.
Publication Date
2014
End of Embargo
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Rights
© 2014 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
Peer-Reviewed
Yes
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openAccess
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Department
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Abstract
Polypropylene mesh for pelvic floor surgery is associated with serious complications ( e.g. erosion). A biodegradable tissue engineered mesh composed of a polylactic acid (PLA) scaffold seeded with autologous cells is a promising alternative.
However, thus far elastin content (important for elastic recoil) in this tissue has been low. We aimed to increase elastin expression and test the resultant tensile properties.
Version
Accepted manuscript
Citation
Osman I, Roman S, Sefat F, Bullock AJ and Chapple CR (2014) Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery. European Urology Supplements. 13(1): 483.
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Article