This is not the latest version of this item. The latest version can be found here.
Loading...
Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development
Shriky, Banah Kelly, Adrian L. Isreb, Mohammad Babenko, Maksims Mahmoudi, N. Rogers, S. Shebanova, O. Snow, T.
Shriky, Banah
Kelly, Adrian L.
Isreb, Mohammad
Babenko, Maksims
Mahmoudi, N.
Rogers, S.
Shebanova, O.
Snow, T.
Publication Date
01/04/2020
End of Embargo
Supervisor
Rights
© 2020 The Authors. Published by Elsevier Inc. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
21/12/2019
Institution
Department
Awarded
Embargo end date
Additional title
Abstract
Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile.
Version
Published version
Citation
Shriky B, Kelly A, Isreb M et al (2020) Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. Journal of Colloid and Interface Science. 565: 119-130.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article