Loading...
The contribution of the right supra-marginal gyrus to sequence learning in eye movements
Burke, M.R. Bramley, P. Gonzalez, C.C. McKeefry, Declan J.
Burke, M.R.
Bramley, P.
Gonzalez, C.C.
McKeefry, Declan J.
Publication Date
2013-12
End of Embargo
Supervisor
Rights
© 2013 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
We investigated the role of the human right Supra-Marginal Gyrus (SMG) in the generation of learned eye movement sequences. Using MRI-guided transcranial magnetic stimulation (TMS) we disrupted neural activity in the SMG whilst human observers performed saccadic eye movements to multiple presentations of either predictable or random target sequences. For the predictable sequences we observed shorter saccadic latencies from the second presentation of the sequence. However, these anticipatory improvements in performance were significantly reduced when TMS was delivered to the right SMG during the inter-trial retention periods. No deficits were induced when TMS was delivered concurrently with the onset of the target visual stimuli. For the random version of the task, neither delivery of TMS to the SMG during the inter-trial period nor during the presentation of the target visual stimuli produced any deficit in performance that was significantly different from the no-TMS or control conditions. These findings demonstrate that neural activity within the right SMG is causally linked to the ability to perform short latency predictive saccades resulting from sequence learning. We conclude that neural activity in rSMG constitutes an instruction set with spatial and temporal directives that are retained and subsequently released for predictive motor planning and responses.
Version
Accepted manuscript
Citation
Burke MR, Bramley P, Gonzalez CC, McKeefry DJ (2013) The contribution of the human right supra-marginal gyrus to sequence learning in saccadic eye movements. Neuropsychologica. 51(14): 3048-3056.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article