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Repeatability and reproducibility of Macular Thickness Measurements Using Fourier Domain Optical Coherence Tomography

Bruce, Alison
; 
Pacey, Ian E.
; 
Dharni, Poonam
; 
Scally, Andy J.
; 
Barrett, Brendan T.
Publication Date
2009
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Keywords
Optical coherence tomography, Retinal thickness, Macula, Image analysis, Repeatability, Reproducibility
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Abstract
To evaluate repeatability and reproducibility of macular thickness measurements in visually normal eyes using the Topcon 3D OCT-1000. Methods: Phase 1 investigated scan repeatability, the effect of age and pupil dilation. Two groups (6 younger and 6 older participants) had one eye scanned 5 times pre and post- dilation by 1 operator. Phase 2 investigated between-operator, within and between-visit reproducibility. 10 participants had 1 un-dilated eye scanned 3 times on 2 separate visits by 2 operators. Results: Phase 1: No significant difference existed between repeat scans (p=0.75) and no significant difference was found pre- and post-dilation (p=0.54). In the younger group variation was low (95% limits ± 3.62 m) and comparable across all retinal regions. The older group demonstrated greater variation (95% limits ± 7.6 m). Phase 2: For a given retinal location, 95% confidence limits for within-operator, within-visit reproducibility was 5.16 m. This value increased to 5.56 m for the same operator over two visits and to 6.18 m for two operators over two visits. Conclusion: A high level repeatability, close to 6 m, of macular thickness measurement is possible using the 3D OCT- 1000. Measured differences in macular thickness between successive visits that exceed 6 m in pre-presbyopic individuals are therefore likely to reflect actual structural change. OCT measures are more variable in older individuals and it is advisable to take a series of scans so that outliers can be more easily identified.
URI
http://hdl.handle.net/10454/6384
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Citation
Bruce A, Pacey IE, Dharni P et al (2009) Repeatability and reproducibility of Macular Thickness Measurements Using Fourier Domain Optical Coherence Tomography. The Open Ophthalmology Journal. 3: 10-14.
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https://doi.org/10.2174/1874364100903010010
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Article
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