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Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women.
Noordam, R. Gunn, D.A. van Drielen, K. Westgate, Gillian E. Slagboom, P.E. de Craen, A.J.M. van Heemst, D.
Noordam, R.
Gunn, D.A.
van Drielen, K.
Westgate, Gillian E.
Slagboom, P.E.
de Craen, A.J.M.
van Heemst, D.
Publication Date
2016-10
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(c) 2016 British Association of Dermatologists. Full-text reproduced in accordance with the publisher's self-archiving policy.
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Abstract
Background: Multiple biomarkers have been associated with hair loss in women, but studies showed inconsistent results.
Objective: We investigated the association between markers of cardiovascular disease risk (e.g., serum lipid levels and hypertension) and aging (e.g., 25-hydroxyvitamin D and insulin-like growth factor) with hair loss in a population of middle-aged women.
Methods: In a random subgroup of 323 middle-aged women (mean age: 61.5 years) from the Leiden Longevity Study, hair loss was graded by three assessors using the Sinclair scale; women with a mean score higher than 1.5 were classified as cases with hair loss.
Results: Every standard deviation increase in HDL cholesterol was associated with a 0.65 times lower risk (95% confidence interval [CI]: 0.46–0.91) of hair loss; for IGF-1 the risk was 0.68 times lower (95% CI: 0.48–0.97) per standard deviation increase, independent of the other studied variables. Women with both IGF-1 and HDL cholesterol levels below the median of the study population had a 3.47 times higher risk (95% CI: 1.30–9.25) of having hair loss.
Limitations: The observational setting limits causal inference of the findings.
Conclusion: Low HDL cholesterol and IGF-1 were associated with a higher risk of hair loss in women.
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Accepted manuscript
Citation
Noordam R, Gunn DA, van Drielen K et al (2016) Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women. British Journal of Dermatology. 175(4): 728-734.
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