A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea-hydrogen peroxide
Rong, Dawen Phillips, Victoria A. Rubio, R.S. Angeles Castro, M. Wheelhouse, Richard T.
Rong, Dawen
Phillips, Victoria A.
Rubio, R.S.
Angeles Castro, M.
Wheelhouse, Richard T.
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2008
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Abstract
A novel, convenient, and high-yielding method has been developed for the preparation of heterocyclic N-oxides. The reaction uses the urea·hydrogen peroxide addition complex as a peroxide source for the in situ generation of trifluoroperacetic acid. The advantages of this method are easy handling of a stable, solid oxidant; high yields and simple removal of excess reagents and by-products.
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Rong, D., Phillips, Victoria A., Rubio, Ramon Sanchez, Angeles Castro, Ma, Wheelhouse, Richard T. (2008) A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea-hydrogen peroxide. Tetrahedron Letters, 49 (48), 6933-6935.
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