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3D printed elastic mould granulation
Okeyo, Clint Chowdhury, D.F. Cheung, K.
Okeyo, Clint
Chowdhury, D.F.
Cheung, K.
Publication Date
2019-02-15
End of Embargo
Supervisor
Rights
© 2018 Elsevier B.V. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
Peer-Reviewed
Yes
Open Access status
Accepted for publication
2018-12-03
Institution
Department
Awarded
Embargo end date
Additional title
Abstract
In the pharmaceutical industry, enhanced process understanding resulting in superior control of product attributes, has the potential to save up to 20% of process engineering and product development costs during drug development. With the aim of achieving enhanced process understating, a novel approach for granulation of fine powders is presented. First, a mould with the desired particle shape and size is created using 3D printing followed by casting using elastomeric material. The formulation is prepared through wet massing and tested as a thin film on flat elastomeric membranes. The thin film itself can be a product but it also gives a good indication of coating performance before coating the patterned elastic membrane with the formulation i.e., 3D printed elastic mould granulation. Results show that following granulation and drying, granules of controlled size and shape (e.g. cubic and 500 μm), strength, friability and flowability can be formed. The method presented may allow for more robust process development in particle engineering.
Version
Accepted Manuscript
Citation
Okeyo C, Chowdhury DF, Cheung K et al (2019) 3D printed elastic mould granulation. Powder Technology. 344: 380-392.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article
Qualification name
Notes
Research Development Fund Publication Prize Award winner, December 2018.