Loading...
Assessing the risk of chemotherapy toxicity and hospital admission due to toxicity: A study of acute chemotherapy toxicity and related hospital admission in a large UK teaching hospital, based on proactive telephone assessment patients
Malton, Samuel R.
Malton, Samuel R.
Publication Date
End of Embargo
Supervisor
Rights

The University of Bradford theses are licenced under a Creative Commons Licence.
Peer-Reviewed
Open Access status
Accepted for publication
Institution
University of Bradford
Department
Faculty of Life Sciences
Awarded
2018
Embargo end date
Collections
Additional title
Abstract
Introduction: Acute chemotherapy toxicity is common and can have negative
effects for the patient and health economy and hospitalisation can be
necessitated.
Aims: To identify the incidence of toxicity and admission, and predictors of
toxicity occurrence, severity, hospitalisation and length of stay.
Method: Data was obtained from a proactive telephone assessment of acute
toxicity 24 hours after administration of a first cycle of chemotherapy to patients
in a large UK NHS teaching hospital.
Results: 1539 patients were studied and the overall incidence of toxicity was
35.6% (530 patients). Disease site and number of chemotherapy agents given
were shown to predict toxicity, with breast and upper gastrointestinal cancers
having a higher likelihood of toxicity. Disease was predictive of toxicity grade,
with urology, gynaecology and lung cancer patients experiencing higher grades
of toxicity than other tumour sites. The rate of hospital admission due to toxicity
was 13.1% (203 patients) and median length of stay 3 days (1-28). The risk of
admission had some risk factors in common with toxicity. Disease and the
number of drugs in the regimen affected the risk of admission, with
gynaecology, head and neck and lung cancer patients and patients who
received 3 drugs having a higher likelihood of admission. Predictors in the subgroups
of breast, colorectal and lung cancer patients did not differ greatly from
the whole population and the number of drugs was shown to be a predictor of
nausea, vomiting and fatigue when explored as secondary outcomes.
Conclusion: The research partly addressed the main aim and highlighted
areas where further research is required.
Keywords
Version
Citation
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Thesis
Qualification name
DPharm