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Cell vs. bacterial viability in the presence of host defence peptides and RGD
Hancock, R.E.W. Devine, D.A. Wood, David J.
Hancock, R.E.W.
Devine, D.A.
Wood, David J.
Publication Date
2015
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© 2015 The Authors. Published by AO Research Insititute Davos. Reproduced in accordance with the publisher's self-archiving policy.
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Yes
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openAccess
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Abstract
More than 2 million people/year suffer a bone fracture in the UK1. Reconstruction of bone defects represents a major clinical challenge and is addressed using a number of medical devices. Although medical device compositions and applications may differ widely, all attract microorganisms and represent niches for medical device associated infections. For open fractures, the risk of infection can be 55%2. These infections are often resistant to many of the currently available antibiotics and represent a huge and growing financial and healthcare burden. The aim of this study was a fundamental understanding of how the presence of host defence peptides (HDPs)3 and/or RGD can influence the outcome of cell vs. bacterial viability and proliferation.
Version
Published version
Citation
Katsikogianni MG, Hancock REW, Devine DA and Wood DJ (2015) Cell vs. bacterial viability in the presence of host defence peptides and RGD. eCells & Materials Supplement. 30(2): 55.
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Type
Conference paper
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Notes
Presented at the conference: eCM XVI - Bone and Implant Infection
June 24-26, 2015, Convention Centre, Davos Platz, Switzerland.