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A concise and straightforward approach to total synthesis of (+)-Strictifolione and formal synthesis of Cryptofolione via a unified strategy
Li, X. Wang, G. Zhang, Z. Yang, Q. Huang, S. Wang, X.
Li, X.
Wang, G.
Zhang, Z.
Yang, Q.
Huang, S.
Wang, X.
Publication Date
2019
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© 2019 Taylor & Francis. This is an Author's Original Manuscript of an article published by Taylor & Francis in Synthetic Communications on 16 Mar 2019 available online at https://doi.org/10.1080/00397911.2019.1580373
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04/02/2019
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Abstract
We describe a concise and straightforward approach to the total syntheses of (+)-Strictifolione and Cryptofolione in the longest linear sequences of four steps and six steps from 3-phenyl propanal and trans-cinnamaldehyde, respectively. The route utilized a titanium tetraisopropoxide/(R)-[1,1'-binaphthalene]-2,2'-diol catalyzed Mukaiyama aldol reaction, indium(0)-promoted Barbier reaction, and olefin cross-metathesis as the key reactions.
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Accepted manuscript
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Li X, Wang G, Zhang Z et al (2019) A concise and straightforward approach to total synthesis of (+)-Strictifolione and formal synthesis of Cryptofolione via a unified strategy. Synthetic Communications. 49(8): 1031-1039.
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Article