Loading...
Synthesis, characterization and antimicrobial analysis of metal-doped (Zn2+ and Ag+) brushite powder for bone regeneration
Aqib, M. Alomar, M. Anwar, A. Naseem, K. Javaid, A. Intisar, A. Khan, Shahzeb Ajaz, H. Khan, I.H.
Aqib, M.
Alomar, M.
Anwar, A.
Naseem, K.
Javaid, A.
Intisar, A.
Khan, Shahzeb
Ajaz, H.
Khan, I.H.
Publication Date
2024-05-21
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
embargoedAccess
Accepted for publication
2024-05-10
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Brushite, or Dicalcium phosphate dihydrate (CaHPO4⋅2H2O), is a well-known calcium phosphate (CaP) found in mineralized tissues and is utilized in medical treatment, particularly in bone powder for bone repair. Brushites with Zn2+ and Ag + ions concentration were synthesized in an aqueous solution using the conventional precipitation procedure. The synthesized brushites were characterized using techniques such as Fourier Transform Infrared Spectroscopy (FTIR), Powder X-ray diffraction (PXRD), Scanning Electron Microscopy (SEM), and bioassays were carried out to evaluate their antibacterial and antifungal activities. The alterations in PXRD and FTIR peak locations demonstrated that zinc and silver ions were effectively inserted into the brushite crystals.
Initial tests revealed that the powders were innocuous, which make them potentially beneficial for mineralized tissue engineering. These brushites exhibited remarkable antimicrobial activities. Zn-doped brushite completely controlled the growth of fungi namely Macrophomina phaseolina and Sclerotium rolfsii at a concentration of 0.0039 mg mL-1 while Ag-doped brushite completely arrested the growth of these fungi at 0.0312 and 0.0039 mg mL-1, respectively. Likewise, both the brushite exhibited remarkable antibacterial activity against Bacillus thuringiensis and moderate activity against Escherichia coli. Brushite compounds coupled with active metal ions, notably Ag+ and Zn2+, demonstrated promise as a distinct class of reactive materials for bone-related applications.
Version
No full-text in the repository
Citation
Aqib M, Alomar M, Anwar A, et al (2024) Synthesis, characterization and antimicrobial analysis of metal-doped (Zn2+ and Ag+) brushite powder for bone regeneration. Materials Chemistry and Physics. 320: 129460
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article