Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents
Maher, A. Croker, D.M. Seaton, Colin C. Rasmuson, Å.C. Hodnett, B.K.
Maher, A.
Croker, D.M.
Seaton, Colin C.
Rasmuson, Å.C.
Hodnett, B.K.
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06/08/2014
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The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5–50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.
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Maher A, Corker DM, Seaton CC et al (2014) Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents. Crystal Growth and Design. 14(8): 3967-3974.
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