Mechanism for Polymorphic Transformation of Artemisinin during High Temperature Extrusion
Kulkarni, Chaitrali S. Kelly, Adrian L. Kendrick, John
Kulkarni, Chaitrali S.
Kelly, Adrian L.
Kendrick, John
Publication Date
2013
End of Embargo
Supervisor
Keywords
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Additional title
Abstract
A novel, green, and continuous method for solid-state polymorphic transformation of artemisinin by high temperature extrusion has recently been demonstrated. This communication describes attempts to understand the mechanisms causing phase transformation during the extrusion process. Polymorphic transformation was investigated using hot stage microscopy and a model shear cell. At high temperature, phase transformation from orthorhombic to the triclinic crystals was observed through a vapor phase. Under mechanical stress, the crystalline structure was disrupted continuously, exposing new surfaces and accelerating the transformation process.
Version
No full-text in the repository
Citation
Kulkarni C, Kelly AL, Kendrick J et al (2013) Mechanism for Polymorphic Transformation of Artemisinin during High Temperature Extrusion. Crystal Growth and Design. 13(12): 5157-5161.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article