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Synthesis of citrate-ciprofloxacin conjugates.

Md-Saleh, S.R.
; 
Chilvers, E.C.
; 
Kerr, Kevin G.
; 
Milner, S.J.
; 
Snelling, Anna M.
; 
Weber, J.P.
; 
Thomas, G.H.
; 
Duhme-Klair, A-K.
; 
Routledge, A.
Publication Date
2009
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Keywords
Citrate-ciprofloxacin conjugates, Antimicrobial activity, Antibiotics, Ciprofloxacin, Synthesis
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Abstract
Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.
URI
http://hdl.handle.net/10454/4843
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Citation
Md-Saleh, S. R., Chilvers, E. C., Kerr, K. G., Milner, S. J., Snelling, A. M., Weber, J. P., Thomas, G. H., Duhme-Klair, A-K. and Routledge, A. (2009). Synthesis of citrate-ciprofloxacin conjugates. Bioorganic & Medicinal Chemistry Letters. Vol. 19, pp. 1496-1498.
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https://doi.org/10.1016/j.bmcl.2009.01.007
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Article
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