Vibrational spectroscopic study of fluticasone propionate
Ali, H.R.H. Edwards, Howell G.M. Kendrick, John Scowen, Ian J.
Ali, H.R.H.
Edwards, Howell G.M.
Kendrick, John
Scowen, Ian J.
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2009
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Abstract
Luticasone propionate is a synthetic glucocorticoid with potent anti-inflammatory activity that has been used effectively in the treatment of chronic asthma. The present work reports a vibrational spectroscopic study of fluticasone propionate and gives proposed molecular assignments on the basis of ab initio calculations using BLYP density functional theory with a 6-31G* basis set and vibrational frequencies predicted within the quasi-harmonic approximation. Several spectral features and band intensities are explained. This study generated a library of information that can be employed to aid the process monitoring of fluticasone propionate.
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Ali HRH, Edwards HGM, Kendrick J and Scowen IJ (2009) Vibrational spectroscopic study of fluticasone propionate. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 72(2): 244-247.
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