Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine.
Forbes, Robert T. Edwards, Anthony D. Shekunov, Boris Yu. Grossmann, J, York, Peter
Forbes, Robert T.
Edwards, Anthony D.
Shekunov, Boris Yu.
Grossmann, J,
York, Peter
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2001
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Abstract
The thermodynamic status of -carbamazepine has been clarified using equilibrium solubility measurements, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), heated X-ray powder diffraction (XRPD), and temperature-controlled X-ray scattering techniques. -Carbamazepine is the least stable of the three well-characterized anhydrous polymorphs of carbamazepine at 25°C. In addition, it was confirmed that -carbamazepine undergoes an exothermic transition to -carbamazepine at 130°C. The novel technique of time-resolved simultaneous small- and wide-angle X-ray scattering has been successfully applied to monitor this transition in situ. It was concluded that -carbamazepine has a monotropic relationship with -carbamazepine.
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Edwards, A.D., Shekunov. B.Y., Grossman, G.J. and York, P. (2001). Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine. Journal of Pharmaceutical Sciences. Vol. 90, No. 8, pp. 1106-1114.
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