Characterization and Biocompatibility Study of Nematic and Cholesteryl Liquid Crystals.
Soon, Chin Fhong Blagden, Nicholas Berends, Rebecca F. Batista Lobo, Samira Javid, Farideh A. Denyer, Morgan C.T.
Soon, Chin Fhong
Blagden, Nicholas
Berends, Rebecca F.
Batista Lobo, Samira
Javid, Farideh A.
Denyer, Morgan C.T.
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2009
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Abstract
Intensive research in bio-engineering has been conducted in the search for flexible biomaterials that could support cell growth and cells attachment. Flexible synthetic materials that support cell growth without the aid of synthetic extracellular matrix proteins are still rare. Cholesteryl liquid crystal containing cholesteryl moieties may have suitable biological affinity. Human keratinocytes (HaCat) were cultured with a nematic liquid crystal and three cholesteryl liquid crystals of different formulation. Subsequently, the trypan blue dye exclusion assay was used to determine cell viability in the liquid crystals. The two classes of liquid crystal were characterized by Differential Scanning Calorimeter (DSC) and polarizing microscope (POM) to understand the nature of the interface material. The cell viability study in medium containing liquid crystals verified that liquid crystals had no effects on cell viability. However, only the surface of cholesteryl liquid crystal has shown affinity to HaCat cells. In addition, cells continued to proliferate in the presence of liquid crystals without a change of medium for eight days. No sign of exothermic and endothermic activities at 370C were observed from the DSC test results for the three samples. Biological and mechanical test result of the cholesteryl liquid crystals has shown that cholesteryl liquid crystals are non toxic and support cell attachment without extracellular matrix protein at very low elasticity.
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Soon, C. H., Youseffi, M., Blagden, N., Berends, R., Lobo, S. B., Javid, F. A. and Denyer, M. (2009). Characterization and Biocompatibility Study of Nematic and Cholesteryl Liquid Crystals. In: Ao, S. I., et al. (Eds.). Proceedings of the World Congress on Engineering 2009, (WCE 2009), July 1 - 3, 2009, London. Hong Kong : Newswood Limited. Vol. II, pp.1872-1875. ISBN:978-988-18210-1-0. Lecture Notes in Engineering and Computer Science (Series).
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