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Process simulation of twin-screw granulator: The effect of screw configuration on size distribution
Arthur, Tony B. Sekyi, Nana Pu, Jaan H.
Arthur, Tony B.
Sekyi, Nana
Pu, Jaan H.
Publication Date
2023-06
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© 2023 The Authors. Chemical Engineering Technology published by Wiley-VCH GmbH
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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openAccess
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2023-02-10
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Abstract
The effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation of complex processes, and analyses is evaluated. Twin-screw granulation modeling was used to investigate the contribution of screw configuration and liquid-to-solid (L/S) ratio on GSD. Lactose and Avicel were the granulating materials. Twelve different configurations were investigated under three feed rates as consistent with literature and at various L/S ratios. Results indicate that kneading elements promote the recovery of 100–1000 µm granules while reducing the production of oversized granules. Higher feed rates support the production of fines and agglomerates, while a low feed rate produces 100–1000 µm granules.
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Citation
Arthur TB, Sekyi NKG, Rahmanian N et al (2023) Process simulation of twin-screw granulator: The effect of screw configuration on size distribution. Chemical Engineering and Technology. 46(6): 1251-1259.
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