Publication

Coaxial Electrospinning of Synthetic/Natural Polymer Combinations for Controlled Release of Active Components in Biomedical Applications

Ali, Afzhan
Publication Date
End of Embargo
Supervisor
Twigg, Peter C.
Sefat, Farshid
Keywords
Coaxial electrospinning, Taylor cone, Active pharmaceutical ingredient, Fibre, Morphology, Extracellular matrix, Polymer, Protein, Polycaprolactone, Gelatin, Hexafluoro-propanol, Controlled release
Rights
Creative Commons License
The University of Bradford theses are licenced under a Creative Commons Licence.
Peer-Reviewed
Open Access status
Accepted for publication
Institution
University of Bradford
Department
School of Engineering. Faculty of Engineering and Digital Technologies
Awarded
2024
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Theses
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PhD Thesis
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Abstract
The project aims to advance coaxial electrospinning techniques for polymer/protein systems, targeting tissue engineering and drug delivery applications. While electrospinning is increasingly utilised in tissue engineering, challenges arise when incorporating active pharmaceutical ingredients due to solubility and release rate limitations. Coaxial spinning addresses these challenges by enabling precise control over release rates and properties. This research focuses on developing coaxial electrospinning processes, with a particular emphasis on incorporating extracellular matrix proteins and biologically active components. By systematically investigating process parameters, this study elucidates the structural and functional properties of coaxial fibres and their implications for biological response. Extensive characterisation techniques, including scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), UV-visible spectroscopy, and transmission electron microscopy (TEM), are employed to analyse fibre morphology, chemical composition, and structural properties. Specifically, polycaprolactone (PCL) as a shell layer demonstrates sustained prolonged release of active components while gelatin as the shell layer facilitates instant release. These findings underscore the versatility and efficacy of coaxial electrospinning in tailoring scaffold properties for diverse biomedical applications. The novelty of this work lies in its extensive exploration of coaxial electrospinning techniques and their application in tissue engineering and drug delivery. By controlling release and scaffold properties, this research contributes valuable insights to the field, paving the way for the development of advanced biomaterials with enhanced therapeutic efficacy.
URI
https://bradscholars.brad.ac.uk/handle/10454/20729
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Type
Thesis
Qualification name
PhD
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