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Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences
Wright, E.P. Day, H.A. Ibrahim, Ali I.M. Kumar, Jeethendra Boswell, L.J.E. Huguin, C. Stevenson, C.E.M.
Wright, E.P.
Day, H.A.
Ibrahim, Ali I.M.
Kumar, Jeethendra
Boswell, L.J.E.
Huguin, C.
Stevenson, C.E.M.
Publication Date
2016-12-22
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© 2016 The Authors. This work is licensed under a Creative Commons
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openAccess
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2016-10-23
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Abstract
There are hundreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif. To appreciate an understanding between the dynamics between these structures and how they can be affected by intervention with small molecule ligands, more i-motif binding compounds are required. Herein we describe how the drug mitoxantrone can bind, induce folding of and stabilise i-motif forming DNA sequences, even at physiological pH. Additionally, mitoxantrone was found to bind i-motif forming sequences preferentially over double helical DNA. We also describe the stabilisation properties of analogues of mitoxantrone. This offers a new family of ligands with potential for use in experiments into the structure and function of i-motif forming DNA sequences.
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Citation
Wright EP, Day HA, Ibrahim AM et al (2016) Mitoxantrone and Analogues Bind and
Stabilize i-Motif Forming DNA Sequences. Nature Scientific Reports. 6: 39456.
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