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Modulation of host biology by Pseudomonas aeruginosa quorum sensing signal molecules: messengers or traitors
Liu, Y. Chan, K. Chang, Chien-Yi
Liu, Y.
Chan, K.
Chang, Chien-Yi
Publication Date
2015-11
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© 2015 Liu, Chan and Chang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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openAccess
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2015-10-20
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Abstract
Bacterial cells sense their population density and respond accordingly by producing various signal molecules to the surrounding environments thereby trigger a plethora of gene expression. This regulatory pathway is termed quorum sensing (QS). Plenty of bacterial virulence factors are controlled by QS or QS-mediated regulatory systems and QS signal molecules (QSSMs) play crucial roles in bacterial signaling transduction. Moreover, bacterial QSSMs were shown to interfere with host cell signaling and modulate host immune responses. QSSMs not only regulate the expression of bacterial virulence factors but themselves act in the modulation of host biology that can be potential therapeutic targets.
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Citation
Liu Y, Chan K and Chang C (2015) Modulation of host biology by Pseudomonas aeruginosa quorum sensing signal molecules: messengers or traitors. Frontiers in Microbiology. 6:1226.
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Article