Transsulfuration Pathway Defects and Increased Glutathione Degradation in Severe Acute Pancreatitis.
Rahman, S.H. Srinivasan, Asha R. Nicolaou, Anna
Rahman, S.H.
Srinivasan, Asha R.
Nicolaou, Anna
Publication Date
2009
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Glutathione depletion is a consistent feature of the progression of mild to severe acute pancreatitis. In this study, we examined the temporal relationship between cysteine, homocysteine, and cysteinyl-glycine levels; total reduced erythrocyte glutathione; gamma-glutamyl transpeptidase activity; and disease severity. Initially, cysteine concentration was low, at levels similar to those of healthy controls. However, glutathione was reduced whilst cysteinyl glycine and gamma-glutamyl transpeptidase activity were increased in both mild and severe attacks. As the disease progressed, glutathione and cysteinyl glycine were further increased in mild attacks and cysteine levels correlated with homocysteine (r = 0.8, P < 0.001) and gamma-glutamyl transpeptidase activity (r = 0.75, P < 0.001). The progress of severe attacks was associated with glutathione depletion, reduced gamma-glutamyl transpeptidase activity, and increased cysteinyl glycine that correlated with glutathione depletion (r = 0.99, P = 0.01). These results show that glutathione depletion associated with severe acute pancreatitis occurs despite an adequate cysteine supply and could be attributed to heightened oxidative stress coupled to impaired downstream biosynthesis.
Version
No full-text in the repository
Citation
Rahman, S. H., Srinivasan, A. R. and Nicolaou, A. (2009). Transsulfuration Pathway Defects and Increased Glutathione Degradation in Severe Acute Pancreatitis. Digestive Diseases and Sciences, Vol. 54, No. 3, pp. 675-682.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article